NANOMEDICINE, NEW DELIVERY TECHNIQUES, AND MORE IMPLICATIONSJune 25, 2012
Yesterday I commented briefly about new advances in nanomedicine, and the promises - both positive and negative - that they hold for the delivery of medicine. In that light, there is also this:
What interested me here was once again the promise of these technologies for cancer treatment, and I draw your attention to these paragraphs:
"siRNA-delivering nanoparticles made of lipids, which Anderson’s lab and Alnylam are also developing, have shown some success in turning off cancer genes in animal studies, and clinical trials are now underway in patients with liver cancer. Nanoparticles tend to accumulate in the liver, spleen and lungs, so liver cancer is a natural target — but it has been difficult to target such particles to tumors in other organs.
"'When you think of metastatic cancer, you don’t want to just stop in the liver,' Anderson says. 'You also want to get to more diverse sites.'
"Another obstacle to fulfilling the promise of RNAi has been finding ways to deliver the short strands of RNA without harming healthy tissues in the body. To avoid those possible side effects, Anderson and his colleagues decided to try delivering RNA in a simple package made of DNA. Using nucleic acid origami — which allows researchers to construct 3-D shapes from short segments of DNA — they fused six strands of DNA to create a tetrahedron (a six-edged, four-faced pyramid). A single RNA strand was then affixed to each edge of the tetrahedron."
As the article notes, but circulating these larger tetrahedral nano-particles, they tend to circulate in the blood longer, and to attach themselves to more tumor cells. The result was that tumors which had been modified to glow showed significant decrease in luminescence, indicating that the method was successful. Indeed, the article notes that the technique is being adapted "to ...(shut off) genes involved in other genetic diseases."
Long ago, when I first wrote The Giza Death Star, I observed that these types of advances would be inevitable, and make possible the scientific fulfillment of ancient texts, with their long life-spans, and indeed, this technology portends to expand life spans. If geneticists, for example, ever do crack that part of the genome that seems responsible for "turning us off" - and geneticists have long puzzled over the fact that we appear to have been designed to live much longer than our current average "three score and ten", then these methods of nano-delivery will go a long way to enhance human longevity.
And there, indeed, is the rub: longevity also means a larger population, and for an elite that has repeatedly stated that we simply have "too many people" and that the world's population will have to be "significantly reduced," the delivery methods also hold a darker - much darker - promise of delivering into their hands an "infallible" method of its accomplishment, one devoid of the nasty complications of other "methods."
See you on the flip side.