MORE ON THAT DNA I-MOTIF STRUCTURE AND “PRECISION ...

Yesterday I blogged about what I suspect will become a major "meme" in the push to get people to voluntarily surrender their genetic information: "precision medicine." As I pointed out yesterday, a new government program is seeking a million volunteers for the study which will cross-correlate individual's genetic information with their health history, lifestyle, and so on, in order to create a new kind of medicine - "precision medicine" - which will avoid the "one size fits all" approach.

As I speculated yesterday, while all of this sounds good and plausible, there may be a very dangerous downside, namely, the development of precision beioweapons, i.e., not bioweapons that target a particular race or even "clan haplogroup" (if I may so speak), but even more precise types of bioweapons that could target specific families, or even specific individuals. As I pointed out, the idea has already made an appearance in fiction, with the television series Blacklist (James Spader and Megan Boone) and the end of its second season. With "precision medicine," I fear we're being given the public "fluff" explanation to sell the idea, and to begin to gather the DNA database to make the latter possibility draw closer to reality.

With that in mind, consider the abstract to this paper that was discovered and shared by Mr. B.G., regarding the curious discovery of a new type of genetic structure, the so-called "I motif" which I blogged about on this site recently (I should point out, I am really concerned here with only one statement in the abstract):

i-Motif DNA: Structure, stability and targeting with ligands

Now, I should confess that I haven't the money to purchase a pdf copy of the full paper to every interesting scientific abstract that people share, but with this one I was tempted. But I refrained, because I suspect that this one statement is sufficient to the purpose of today's high octane speculation. Recall that those i-motif four-stranded knots of DNA appear to be some sort of genetic regulatory structure in cells, according to the best contemporary thinking. They thus appear and disappear under certain conditions, in this case, the pH levels of cells. With that in mind, and with my speculations from yesterday about the darker uses of "precision medicine" in mind, consider this statement from the abstract:

By virtue of their pH dependent folding, i-motif forming DNA sequences have been used extensively as pH switches for applications in nanotechnology.

Now again, I'm no scientist of any sort, and certainly I'm far removed from being any sort of geneticist or biological engineer, but it strikes me - as it struck Mr. B.G. in his original email bringing this paper to my attention - that not only is this a potential delivery mechanism for "precision medicine" but also for the sorts of narrowing target-specificity for bio-warfare that I was entertaining in yesterday's blog. On the positive side, imagine being able to deliver nanobots to repair damaged cells (or for that matter, to target diseased cells), based on the local pH conditions of the body, or based on some other biological marker of ill-health. Similarly, however, it could be used to deliver to a mass population, a bioweapon that would and could only be activated by a specific set of programmable parameters, for a clan, a family, an individual.

The bottom line? I suspect that when Mr. B.G. read my blog about the i-motif, and noticed this paper and alluded to these possibilities in his email, that he is on to something.

See you on the flip side...

 

 

18 thoughts on “ MORE ON THAT DNA I-MOTIF STRUCTURE AND “PRECISION ...”

  1. wasn’t it in ‘brave new world’ that perceived enemies of the stat were targeted by robot dogs that had been given the targets dna and they were pursued until cornered and killed? the hero somehow avoided this and knew someone else had been killed-live on the tv because the robodogs never failed

  2. . . . Sharing early stage research has become more and more scant due to who will cash-in and how they will they control it. A tidbit of detail can tip the scholarly balance and legal quest of patents and awards to the point of unfair exclusion where credit is due. Unless one has a modest grasp of terminology it will seem little more than gibberish to the untrained technicians ears, unfamiliar academic major, and busy doctorate too absorbed in their own work.

    Beckoning necessity, one needs to be quick on the up-take of idioms and jargon one is exposed to, essentially, come to task and realization that language, that familiar conundrum of words most folks assume they can handle, that it is a lengthy, it is linear, and it is imprecise from the start in determining this thing called research and development of science that is transformed later into made-public publications. . . Many sources of grant and funding monies hint at join-the-club, pay your dues for continued access and sustenance, or find another job before tooting what one just happened to come across during experimentation in idle conversation.

    I remain dubious about how well this science will continue with a level of treachery one thought was only the gift of cunning Feringi’s practicing their Rules of Acquisition on a Hollywood production. One can at least script a remedy into the narrative. . . Besides, the scientist-technicians are already up against a tainted environment that has effects on bio-cellular growth – Especially, the abnormal growths. . . Ask yourself, “How does one separate observer-experimenter bias within an experiment when it has a multitude of contaminants that role play as they taint the experiment from the beginning?”. . . Let’s see, . . One just hedges a bit and hopes it gets lost in assumptions of negligibility by those doctorates not up on the nit-picking details no-one really understands anyway. . .

    Now let loose, as you say, some of that “high octane speculation” with a portion of updated terminology and a touch of results before sanitizing those ‘you-know-not-what-you-got-results’ for eager novices in the field learning the ropes and maybe the returns will be profitable for all participants. It’s not what is shared in publications that are at issue. Copyright infringements are taken very seriously these days with a time-stamp included. It’s the unpublished juicy, bewildering, and “WHAT?” results that are missing headlines for the information starved academics who’ll likely benefit if given the opportunity for their curiosity. . .

    One’s DNA is already a matter of record while participating in research. . . No reports on my samplings developing into un-retainable laboratory escapees of humanoid form yet. 0 – 3, so far, apparently my DNA is behaving normally with all three facilities or within tolerable parameters. . . No hint that I took over, anyway, demanding compensation in small bills. I don’t expect much from military processes and know better not to. . . Just what was that papers problem again in jargonized rants? . .

    Thanks for this

  3. Always the last to know.–does the quoted statement not imply they’ve been fully aware of Imotif’s existence and capabilities, and have been using it for some time?

    “By virtue of their pH dependent folding, i-motif forming DNA sequences have been used extensively as pH switches for applications in nanotechnology.”

  4. Shoul Tucker and the rest of the state alchemists of Fullmetal Alchemist who have a ball with this technology. I think even Victor Frankenstein would be interested in using this in his experiments.

  5. Reminds me of the sumerian depiction of Ningishzidda and Enki with the ankh in the middle as the i-motif connected to the DNA strand. Also, if you plot the cross points on paper, it forms a tree of life pattern.

  6. Let me invert the objective around the collection of a million samples of DNA for the invention of a precision bioweapon:

    What if you were not trying to “target a particular race or even ‘clan haplogroup’ “? What if you were planning a general release of something, and wanted to ensure that your favorite Tribe was not effected?

    You would still want a massive database to generate the “is here, is not there” genetic foundation. However, you would be structuring the project around ‘ignoring’ a tiny population (percentage-wise) and ‘infecting’ the vast majority. Sort of a non-nuclear Samson Option…

    1. i’d argue that’s already the fundamental pattern of tactic and strategy mr global is universally applying. if nothing else comes to mind, consider how our currencies are worked. they probably don’t care which way the tide is going as long as it’s going as radically as possible. which gives them a better crisis to capitalize on.

  7. Precision-wallet medicine designed to drain the remaining strength of your economic velocity, in & of currency and/or wherewithal. They are target shopping for believers in their virtues of leadership as spread by another symbolic mainlining mainstream

  8. “By virtue of their pH dependent folding, i-motif forming DNA sequences have been used extensively as pH switches for applications in nanotechnology”

    “… and as binding sites for nanobots, also known as Morgellon’s disease.”

    _________________________________________________________________________

    There, that’s what’s behind the paywall. Or should be.

    I’d also add that this structure — since it is both transitory and pH dependent — could well be involved with activating cancer defenses, as cancer thrives in a body with a high pH imbalance. It could be the genetic tripwire and is first formed when things are getting out of whack. This could also be why there’s so much interest in it — doubtless to short-circuit it, knowing how psychopathic everything is these days.

    1. and why there’s so much wet work going down to kill scientists and doctors who are bringing out more accurate perspectives on ideas like nagalese and GcMAF and vaccines,… if this amurican stalinization continues look for anyone who’s tested and learned any fundamental science that allows for better health (think pottenger and his 5th generation of well fed cats) to be considered as worthy of the presidents secret drone courts.

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